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CD47-blocking antibodies restore phagocytosis and prevent

Validated in IHC, WB and tested in Human, Rat. Size: 100&mug/vial.Size: 100ug/vialSource: RabbitReactivity: Human, Antikroppsnamn, CD47 molecule. Antikroppstyp, Primary. Klonalitet, Polyclonal. Konjugation, Unconjugated. Reaktivitet, Human. Värd, Rabbit.

CD47 is an approximately 50 kDa glycosylated five transmembrane protein that is ubiquitously expressed by both hematopoietic cells such as T and B lymphocytes, monocytes, platelets and erythrocytes and non-hematopoietic cells. Magrolimab is a first-in-class investigational monoclonal antibody against CD47 and macrophage checkpoint inhibitor that is designed to interfere with recognition of CD47 by the SIRPα receptor on macrophages, thus blocking the "don't eat me" signal used by cancer cells to avoid being ingested by macrophages. Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu72 of human CD47 protein. Background CD47 is a five-pass transmembrane protein expressed on all normal cells. CD47 Antibody (OX101) is a mouse monoclonal IgG 1 (kappa light chain) provided at 200 µg/ml; raised against thymocytes of rat origin; Anti-CD47 Antibody (OX101) is recommended for detection of CD47 of mouse and rat origin by WB, IP, IF, IHC(P) and FCM CD47 is a kind of protein that is found on the surface of many cells in the body. It tells circulating immune cells called macrophages not to eat these cells. The body uses the CD47 protein to protect cells that should be protected and to help dispose of cells that are aged or diseased.

cancer using recombinant antibody microarrays. European Journal of Cancer, 44 torer, neoantigenvacciner och CD47-blockad3.

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Specificity: This antibody reacts with Ig domain of CD47 protein. CD47, originally named integrin-associated protein (IAP), is a 50kDa protein containing five membrane-spanning sequences and a short cytoplasmic tail. Immunohistochemistry-Paraffin: CD47 Antibody (B6H12.2) - Azide Free [NBP2-31106] - Tissue section of human normal breast using mouse monoclonal CD47 antibody (clone B6H12.2) at 0.5ug/ml concentration.

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Two splice variants have been described in the cytoplasmic tail, the shorter form is expresse CD47 also known as Rh-associated protein, gp42, integrin-associated protein (IAP), and neurophilin, is a 42-52 kD member of the immunoglobulin superfamily containing a five-pass transmembrane attachment. 2020-01-13 · CD47, the integrin-related protein, plays an important role in immune resistance and escape of tumor cells. Antibodies blocking the CD47/SIRPα signal pathway can effectively stimulate macrophage-mediated phagocytosis of tumor cells, which becomes a promising approach for tumor immunotherapy.

Antigen-Antibody Reactions.
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Among its related pathways are Integrin Pathway and Cell surface interactions at the vascular wall.

CD47 is a receptor for thrombospondin-1 (TSP-1), a secreted glycoprotein that plays a role in vascular development and angiogenesis. CD47 Is has been found to be overexpressed in many different tumor cells. Because of this, anti-CD47 monoclonal antibodies have been proposed and studied as a therapeutic treatment for human cancers.
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It tells circulating immune cells called macrophages not to eat these cells. The body uses the CD47 protein to protect cells that should be protected and to help dispose of cells that are aged or diseased. CD47 (C luster of D ifferentiation 47) also known as integrin associated protein (IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα).

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conventional dendritic cells induce T follicular helper cell-dependent antibody CD47-deficient mice have decreased production of intestinal IgA following By using antibodies to LRP1 or receptor?associated protein (RAP), CD47 on the target cell inhibited LRP1?mediated phagocytosis of viable cells (e.g.