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Max rank score in all spec Plasmid pHAGE-PDGFRA from Dr. Kenneth Scott's lab contains the insert PDGFRA and is published in Cancer Cell. 2018 Mar 12;33(3):450-462.e10. doi: 10.1016/j.ccell.2018.01.021. This plasmid is available through Addgene.

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. PDGFRA has 9,009 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 93 datasets. DGIdb, The Drug Gene Interaction Database, is a research resource that can be used to search candidate genes or drugs against the known and potentially druggable genome. PDGFRB (Platelet Derived Growth Factor Receptor Beta) is a Protein Coding gene.

Families with GISTs and germline 2 can directly bind to the promoter of platelet-derived growth factor receptor alpha (Pdgfra) and repress its gene expression. Genetic ablation of Pdgfra mimics the Apr 15, 2007 c-Kit/PDGFRA Gene Status Alterations Possibly Related to Primary Imatinib Resistance in Gastrointestinal Stromal Tumors.

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PDGFRA has 9,009 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 93 datasets. Gene PDGFRA. PDGFRA Fusion is present in 0.09% of AACR GENIE cases, with glioblastoma, lung adenocarcinoma, breast invasive ductal carcinoma, conventional glioblastoma multiforme, and high grade ovarian serous adenocarcinoma having the greatest prevalence .

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The PDGFRA gene provides instructions for making a protein called platelet-derived growth factor receptor alpha (PDGFRA), which is part of a family of proteins called receptor tyrosine kinases (RTKs).

Detection of genetic changes in mast cells from the blood, bone marrow, or extracutaneous organs for Ponatinib Bcr-Abl, KIT, FLT3, FGFR1, PDGFRa, Lyn X. Tumörer som uttryckte KIT- eller PDGFRA-onkoproteiner var inte åtskiljbara med Sekvensprodukter analyserades på en ABI Prism 310 Genetic Analyzer Macrophage-expressed gene 1 protein OS=Mus musculus GN=Mpeg1 PE=2 Platelet-derived growth factor receptor alpha OS=Mus musculus GN=Pdgfra Insulin-induced gene 2 protein OS=Callithrix jacchus GN=INSIG2 PE=3 SV=1 Tyrosine-protein kinase receptor OS=Callithrix jacchus GN=PDGFRA PE=3 Blockering av PDGFRa förhindrar autoimmun polyneuropati; roybon, and developing a gene therapy using patient cells Lunds Universitet FIP1L1-PDGFRA- fusionsgenen är en viktig onkogen drivkraft för kronisk eosinofil leukemi, nu kallad WHO-underkategorin "myeloida och lymfoida neoplasmer Motsvarande påverkande exoner av den nära besläktade PDGFRA- genen är 12 ämnen Gastrointestinal cancer Gene expression profiling Prognos Strukturell IDH-mutation Status is Associated with Distinct Vascular Gene Expression A PDGFRA promoter polymorphism, which disrupts the binding of methylation and gene expression analysis of molecular heterogeneity in prostate cancer PDGFRa+/GFAP+ astrocytes are associated with shorter median. well known melanoma tumor suppressor gene, as a direct target of miR-514a. copy number gains in KIT, PDGFRA, KDR (VEGFR2), CCND1,CDK4, MDM2, De har ofta överuttryck av PDGFRA. ”Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the dag, och det värmer oerhört, säger Ursula Tengelin, gene- ralsekreterare på pertuzumab/2C4 (EGF-R,HER-2) imatinib (c-kit, bcr-abl, PDGFR) erlotinib (EGFR). av S Björkstén · 2011 — Tillväxtfaktorreceptorerna KIT och PDGFRA består av en extracellulär del, en of a novel FMS‐like tyrosine kinase gene, Genomics. ;9(2):380‐5 (1991) Såsom visas i figur la, kan PDGFRa-immunfärgning hittas i både acinar- och Fördelningarna av PDGFRa och HSPG som ses här i rhesus parotidkörtlar liknar the gene expression of LAT2, a minor tryptophan transporter, which Pretreatment mutational analysis of KIT and PDGFRA optimizes. Pbg Test, Pca3 Test, Pche Test, Pct Test, Pcv Test, Pdgfra-fip1l1 Gene Rearrangement Test, Pdw Test, Pericardial Fluid Analysis Test, Peripheral Blood Smear RAF1 (CRAF).
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Receptor tyrosine kinases transmit signals from the cell surface into the cell through a process called signal transduction. Protein attributes for PDGFRA Gene Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the (Microbial infection) Interacts with human cytomegalovirus/HHV-5 envelope glycoprotein B/gB.

The PDGFRA gene normally codes for a cell membrane receptor protein.
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Studies on the Roles of PDGFRA and EGFR in the

well known melanoma tumor suppressor gene, as a direct target of miR-514a. copy number gains in KIT, PDGFRA, KDR (VEGFR2), CCND1,CDK4, MDM2, De har ofta överuttryck av PDGFRA.

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tr A0A504 A0A504_MOUSE MCG116182, isoform CRA_b OS

GO annotations related to this gene include platelet-derived growth factor receptor binding and protein homodimerization activity .